International Society for Pharmacoepidemiology
 
International Society for Pharmacoepidemiology

18th International Conference on Pharmacoepidemiology (ICPE)

August 18-21, 2002
Edinburgh Conference Centre
Heriot-Watt University
Edinburgh, Scotland

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Preliminary Agenda
NOTE: Visit this site for updates.
Last Update: July 18, 2002


Saturday, August 17

9:00-10:30 ISPE Finance Committee (Cedar)
11:00-1600 ISPE Board of Directors Meeting (Cedar)
1900-21:30 Board Dinner (By Invitation Only)

Sunday, August 18

09:30-10:45 ISPE Committee Meetings
(Open to all interested ISPE Members)
Data Privacy Committee (Wardlaw A)
Membership & Public Relations Committee (Wardlaw B)
10:45-12:00 ISPE Committee Meetings
(Open to all interested ISPE Members)
Bylaws & Policy Committee (Wardlaw A)
Public Policy Committee (Wardlaw B)
Membership & Public Relations Committee (Bruce)
12:00-17:30 Registration (James Watt Lounge)
13:00-18:00 PRE-ICPE EDUCATIONAL SESSIONS
[A]   Introduction to Pharmacoepidemiology (Lecture 4)
Jacques LeLorier, Confounding by Indication
Judith Jones, Cohort Studies
Sean Hennessy, Case-Control Studies
Nicolas Moore, Pharmacovigilence
[B]   Advanced Topics in Pharmacoepidemiology (James Watt)
Stephen Evans
Wayne Ray, Automated Databases: Beyond the Basics
TBA
15:30-16:30 Meeting, National Drug Utilization Research Groups (Cedar)
16:30-17:30 EuroDURG General Assembly (Cedar)
18:00-18:45 Council Meetings (open to all interested attendees)
Academic Council (TBD)
Industry Council (TBD)
Government Council (TBD)
19:00-22:30 WELCOME RECEPTION & CEILIDH (Hall)
(Cash Bar)

Monday, August 19

06:00-08:00 Exhibitor Set-up (Hall)
07:00-8:00 Poster Set-up (Session A) (Hall)
07:00-5:00 Registration (James Watt Lounge)
Speaker Ready Room
08:30-10:00 OPENING SESSION (James Watt)
    Welcome
      Thomas MacDonald, Chair, Scientific Program Committee
      Roland T. Jung, Chief Scientist for Scotland

    Presidential Address

      Jacques LeLorier, President, ISPE

    Keynote Address

      Alasdair Breckenridge
      For the good of the patient: risks and benefits of medicines

10:00-10:30 Refreshment Break/Viewing of Posters & Exhibits (Hall)
10:30-12:15 CONCURRENT SESSIONS
  1. SYMPOSIUM: Pharmacoeconomics/Outcomes Research
    (James Watt)
    Moderator:
    Peter Davey

    PANELISTS:
    Maarten Postma
    David Henry
    Andrew Walker

  2. SYMPOSIUM: Pharmacogentics
    (Lecture 4)
    Moderator:
    Munir Pirmohamed

    PANELISTS:
    Roland Wolf
    Research developments and practical applications in pharmacogenetics.

    Diederick E Grobbee

    ACE-ID and APOE Gene-Drug Interactions in Statin Therapy [26 & 35]
    Anke Hilse Maitland-van der Zee, The Netherlands. Recipient of the 2002 Edlavitch Award

    Potential Interaction between Acenocoumarol and Diclofenac, Naproxen and Ibuprofen and the Role of CYP2C9 Genotype [162] Karen N van Dijk, Arian W Plat, Alieke AC van Dijk, Margriet Piersma-Wichers, Jennita Slomp, Lolkje TW de Jong-van den Berg, Jacobus RBJ Brouwers (The Netherlands)

    Variation in the Gene for the Glycogen Targeting Subunit of Protein Phosphatase-1 (PPP1R3A) Is Associated with Lipid Levels and Cardiovascular Risk in Type II Diabetics in Tayside, Scotland [405] Alexander Doney, Bettina Fischer, Douglas Boyle, Andrew Morris, Patricia Cohen, David Frew, Colin Palmer (United Kingdom)
12:30-14:30 *Lunch (Dining area) *Poster Session A/Viewing of Exhibits (Hall)
*EuroDURG Executive Committee (By Invitation Only) (Cedar)
12:30-13:30 ISPE Committee Meetings
Publications Committee
Development Committee
13:30-14:30 ISPE Annual Meeting of Members (James Watt)
(Open to all participants)
    Annual Reports
    Awards Ceremony
      Distinguished Service Award: Hugh Tilson
      Student Awards
        Edlavitch Award (Best Student Abstract):
         Anke Maitland-van der Zee
        2nd Best Student Abstract: David Spiro
        3rd Best Student Abstract: Joelle Erkens
        Best Student Methods Abstract: Maarten ten Berg
        Best Student Drug Utilization Abstract:
         Willeke Kasje
      ISPE-PDS Prize
14:30-16:00 CONCURRENT SESSIONS
(15 minute oral abstract presentations)
[A] Methods in Pharmacovigilance (Lecture 4)
Moderator: Karen Wilcock & Ineke Neutel
14:30 Communication with Patients Increases Capture of Etanercept Post-Marketing Adverse Events [440] Diana F Sabath, Wayne J Wallis, Thy P Do, Tom W Brethauer, John Goodleaf, Joan Holman, Daniel J Burge, Dawn Viveash
14:45 A Replication of the Weber Effect Using Post-Marketing Adverse Event Reports Submitted to the SRS and AERS [186] Nicole R Crawford, James P Wilson
15:00 Implementation of a Computer Monitoring System for Detection of Adverse Drug Reactions by Laboratory Signals [362] Manfred Criegee-Rieck, Antje Neubert, Harald Dormann, Tobias Egger, Arnim Geise, Eckhardt G Hahn, Kay Brune (Germany)
15:15 Influence of Backgrounds in Proportional Analysis [358] Victor V Gogolak, Ralph Edwards
15:30 Data Mining: A Pharmacovigilance Tool for the Evaluation of Drug Interactions in the Post-Marketing Setting [383] June S Almenoff, William H DuMouchel, Xionghu Yang, Allen L Kindman, David M Fram
15:45 Understanding Quantitative Signal Detection Methods in Spontaneously Reported Data [443] Andrew J Bate, Marie Lindquist, Ivor Ralph Edwards, Roland Orre (Sweden)
[B] There Ought to be a Law (Lecture 3)
Moderators: Miles Braun & Rizwan Ahmed
15:30 Ensuring Public Confidence in Vaccine Safety: Some Lessons from Enron and Other Public Fiascos [467] Robert T Chen
14:45 The Public's Obligations and Rights with Regard To Providing Data for Research [442] Ingunn Björnsdóttir, Janine Morgall Traulsen (Iceland)
15:00 Use of Electronic Medical Records in Family Physicians¢ Offices for Research: Privacy Concerns of Patients [446] Donald J Willison, Karim K Keshavjee, Kalpana Nair, Anne M Holbrook, Charlie Goldsmith, Sue Troyan (Canada)
15:15 A Consent-Based Stroke Registry: If You Build It, Will They Come? [448] Donald J Willison, Pierrot Peladeau, Frank L Silver (Canada)
15:30Drug Prices Comparison for the Reimbursable Medicines among Some East European Countries [190] Jan Komrska, Sasha Spasic, Jane Arsov, Bistra Angelovska, Guenka Petrova (Bulgaria)
15:45Do Doctors Rely on Pharmaceutical Industry Funding To Attend Conferences and Do They Perceive That This Creates a Bias in Their Drug Selection? - Results of a Questionnaire Survey to Edinburgh Doctors [143] Philip Rutledge, David Crookes, Brian McKinstry, Simon RJ Maxwell (United Kingdom)
[C]Gastroenterology (James Watt)
Moderator: Nicolas Moore & Jesper Hallas
14:30 The Risks of Upper Gastrointestinal Haemorrhage (UGIH) in Users of Meloxicam, Cyclooxygenase-2 (COX-2) Specific Inhibitors and Other Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) [30] Thomas M MacDonald, Daniel A Pettitt, Jay L Goldstein, Tom A Burke, Sean Z Zhao, Steve V Morant (United Kingdom)
14:45Declining Hospitalization and Mortality Rates from Peptic Ulcer Disease in the 1990s: Correlation with Sales of NSAIDs and Acid Suppression Medications [31] James D Lewis, Warren B Bilker, Colleen Brensinger, John T Farrar, Brian L Strom
15:00The Risk of Esophageal Obstruction Associated with an Anti-Allergy Medication (Claritin-D 24 Hour)® [260] Bharati Manda, Deborah Shatin, David Graham, Carol Drinkard
15:15A Swedish Case Control Network of Drug Induced Morbidity - Acute Pancreatitis [138] Kerstin B Blomgren, Anders Sundström, Gunnar Steineck, Sven Genell, Svante Sjöstedt, Bengt E Wiholm (Sweden)
15:30Irritable Bowel Syndrome and Medical Resource Use [112] Eric Van Ganse, Michel Dapoigny, François Dyard, Jean Charles Grimaud, Philippe Guyot (France)
15:45Risk Factors for Hospitalized Complications of Constipation: A Case-Control Study [262] Alexander M Walker, Rhonda L Bohn, Clorinda M Cali, Suzanne F Cook, Bruce E Sands
[D]Hormones out of Control (Lecture 4)
Moderator: Jean-Pierre Gregorie
14:30Tibolone and Endometrial Cancer: A Nested Case-Control Study in the United Kingdom [422] Corinne S de Vries, Susan E Bromley, Timothy J Williams, Hilary Thomas, Richard DT Farmer (United Kingdom)
14:45 Risk of Edema in Diabetic Patients Treated with Thiazolidinediones [451] Odile Sheehy, Jacques LeLorier, Jean-Louis Chiasson (Canada)
15:00 Use of Fluorquinolones Is Associated with a Reduced Risk of Coronary Heart Disease in Diabetes Mellitus Type 2 Patients [13] Joëlle A Erkens, Olaf H Klungel, Ron MC Herings, Ronald P Stolk, José A Spoelstra, Diederick E Grobbee, Hubert GM Leufkens (The Netherlands)
15:15 Pharmaceutical Content and Regimen of Hormone Replacement Therapy and Risk of Breast Cancer [296] Diane S Allen, Corinne S de Vries, Richard DT Farmer (United Kingdom)
15:30Hormone Replacement Therapy and Risk of Acute Myocardial Infarction [314] Susan E Bromley, Corinne S de Vries, Richard DT Farmer (United Kingdom)
15:45Antihypertensive Drug Therapy and the Risk of Lower Extremity Amputations in Type 2 Diabetes Mellitus Patients [11] Joëlle A Erkens, Olaf H Klungel, Ronald P Stolk, José A Spoelstra, Diederick E Grobbee, Hubert GM Leufkens (The Netherlands)
[E] Disease Epidemiology (Lecture 1)
Moderator: Ken Rothman
14:30Cardiovascular Comorbidity in the US Elderly Population with Renal and Glucose Metabolism Impairment: The Third National Health and Nutrition Examination Survey [116] Cristina Varas-Lorenzo, Ana M Rueda de Castro, Andrew Maguire, Montserrat Miret, Carles Blanch (Spain)
14:45Prevalence of Glucose Metabolism abnormalities and Cardiovascular Comorbidity in the US Elderly. The Third National Health and Nutrition Examination Survey (1998-1994) [140] Cristina Varas-Lorenzo, Ana M Rueda de Castro, Andrew Maguire, Montserrat Miret, Carles Blanch (Spain)
15:00Risks Associated with Concomitant Respiratory Disease in Diabetes [373] Irene V Farquhar, Kent H Summers
15:15 Epidemiology of Respiratory Syncytial Virus-Related Illness in the United States: An Analysis of National Databases [36] L Clark Paramore, Vincent Ciuryla, Gabrielle Ciesla, Zhiyuan Liu
15:30 The Occurrence of Colonic Ischemia, Complications of Constipation, and Bowel Surgery in Relation to Irritable Bowel Syndrome [63] J Alexander Cole, Suzanne F Cook, Anuli N Ajene, David P Miller, Alexander M Walker
15:45 Incidence of Acute Myocardial Infarction in Women in the UK: Secular Trends and the Association with Menopause [313] Susan E Bromley, Corinne S de Vries, Richard DT Farmer (United Kingdom)
16:00-16:30 Refreshment Break/Viewing of Posters & Exhibits (Hall)
16:30-18:00 CONCURRENT SESSIONS (15 minute oral abstract presentations)
[A] Spontaneous Reports/Pharmacovigilance (Lecture 3)
Moderator: Valerie Simmons
16:30 Evaluation of the ClozarilÒ Patient Monitoring Service (CPMS) in the Prevention of Clozaril/Leponex Induced White Blood Cell Toxicity [386] Alejandro Arana, Javier Cid Ruzafa, Ana M Rueda de Castro, Barbara A Warner, Des O'Sullivan (Spain)
16:45 The Association of Suicidal Behaviour with Selective Serotonin Reuptake Inhibitors (SSRIs). Treatment or Condition? [231] Cheryl Key (United Kingdom)
17:00 Drug Safety Issues Related to Etanercept and Infliximab: An Analysis Based on WHO/UMC Safety Database [83] Sean Z Zhao, Matthew W Reynolds
17:15 Safety Profile of Rofecoxib as Used in General Practice in England: Results of a Prescription-Event Monitoring Study [121] Deborah Layton, Jayne Riley, Lynda V Wilton, Saad AW Shakir (United Kingdom)
17:30 Signal Generation in Prescription Event Monitoring: Investigation of a Possible Signal of Colitis during Rofecoxib Treatment [102] Emma L Heeley, Deborah Layton, Saad A Shakir (United Kingdom)
17:45 Adverse Drug Reactions Associated with Hospitalisations in South Australia: Trends over 13 Years [74] Elizabeth R Roughead, Susan J Semple (Australia)
[B] Global Pharmacoepidemiology and Anti-infectives (Lecture 2)
Moderators: Byung Joo Park & Samuel Lesko
16:30 Antibacterial Use and Resistance in a Large Teaching Hospital in Tehran, Iran [270] Faranak Ansari, Zohreh Rostami, S Mansor Razavi (United Kingdom)
16:45 Antibiotic Use Profile at Pediatric Clinics in Two Transitional Countries [289] Goran Palcevski, Svetlana Ratchina, Vesna Rosovic-Bazijanac, L Averchenkova, Vladimir Ahel (Croatia)
17:00 Self-Purchasing of Antibiotics by Russian Townspeople [471] L. S. Stratchounski, I. V. Andreeva, S. A. Ratchina, D. V. Galkin, N. A. Petrotchenkova, A. A. Demin, V. B. Kuzin, S. T. Kusnetsova, R. Y. Likhatcheva, S. V. Nedogoda, E. A. Ortenberg, A. S. Belikov, I. A. Toropova (Russian Federation)
17:15 Utilization of Antimicrobials in Rijeka (Croatia)) [215] Vera Vlahovic-Palcevski, Vesna Rosovic-Bazijanac (Croatia)
17:30 Epidemiology and Economy of Antibiotics Usage during Hospital Pneumonia Management in a Region of Belarus [376] Maksim Nikolay Mily, Sergey Alexander Golubev, Vladimir Yeugen Lugovoy, Gennadiy Gennadiy Voronov (Belarus)
17:45 Quality Predictors of Traditional Drugs Produced in Thailand [42] Arthorn Riewpaiboon, Rungravi Temsiririkkul, Malyn Chulasiri (Thailand)
[C] Multiple Drug Classes (Lecture 1)
Moderator: Judith Jones
16:30 Drugs Associated with a Protective Effect on Non-Hodgkin's Lymphoma [176] Annette B Beiderbeck, Elizabeth A Holly, Miriam CJM Sturkenboom, Jan-Willem W Coebergh, Bruno HCh Stricker, Hubert GM Leufkens (The Netherlands)
16:45 Folic Acid and Oral Cleft: A Case-Control Study in the United Kingdom [423] Corinne S de Vries, Man Chie Chow, Richard TD Farmer, Lolkje TW de Jong-van den Berg (United Kingdom)
17:00 Folic Acid and Oral Cleft: A Case-Control Study in the United Kingdom [423] Corinne S de Vries, Man Chie Chow, Richard TD Farmer, Lolkje TW de Jong-van den Berg (United Kingdom)
17:15 Drugs Associated with Increased Risk of Non-Hodgkin¢s Lymphoma [180] Annette B Beiderbeck, Elizabeth A Holly, Miriam CJM Sturkenboom, Jan-Willem W Coebergh, Bruno HCh Stricker, Hubert GM Leufkens (The Netherlands)
17:30 Adverse Drug Events Caused by Medication Errors in Medical Inpatients [46] Beat Hardmeier, Suzanne Braunschweig, Marzia Cavallaro, Malgorzata Roos, Peter J Meier, Karin Fattinger (Switzerland)
17:45 A Post-Marketing Cohort Study of Leflunomide and Other DMARDs: A Comparative Risk Analysis [225] William L Holden, Juhaeri Juhaeri, Wanju Dai
[D] Case Control & Cohort Studies (James Watt)
Moderator: Wayne Ray
16:30 The Relative and Population Attributable Risk of Non-RTA Vertebral and Non-Vertebral Fracture in Patients Taking Oral and/or Inhaled Corticosteroids [244] Peter T Donnan, Gillian Libby, Anne C Boyter, Phillip Thompson (United Kingdom)
16:45 Hetastarch and Bleeding Complications after Coronary Artery Surgery [397] Jerry Avorn, Minalkumar Patel, Raisa Levin, Robert J Glynn, Wolfgang C Winkelmayer
17:00 Factors Associated with Allograft Rejection among Renal Transplant Patients in the U.S. [108] Donnie P Funch, Hnin Hnin Ko, Diana Grigsby, Jacqueline Travasso, Alexander M Walker
17:15 Concomitant Use of Sildenafil and Nitrates and Risk of Ischemic Events [302] Patrick C Souverein, Toine CG Egberts, Eric JH Meuleman, John Urquhart, Hubert GM Leufkens (The Netherlands)
17:30 Descriptive Epidemiology of Early-Onset Adverse Effects of Cancer Chemotherapy [156] Sean Hennessy, Carol A Carozzoni, Mark G Weiner, Gene A Gibson, Alice Livshits, Warren B Bilker, Erin McMenamin, M Anne Blackwood-Chirchir, Jeffrey H Silber
17:45 Safety and Efficacy of Ondansetron Following Exposure during Pregnancy:A Prospective Comparative Study [67] Adrienne Einarson, Kiran Chandra, Maltepe Caroline, Navois Yvette, Koren Gideon (Canada)
[E] Provocative Methods (Lecture 4)
Moderator: Alec Walker
16:30 Improved Comorbidity Adjustment in Epidemiologic Studies Using Medicare Claims Data [305] Sebastian Schneeweiss, Pilip S Wang, Jerry Avorn, Robert J Glynn
16:45 Adjustment Using the Propensity of Adherence: Theory, Simulation and Practical Application [429] Jixian Wang, Li Wei, Thomas M MacDonald (United Kingdom)
17:00 Back-to-the-Future Bias in Cohort Studies of Drug Effectiveness [328] Samy Suissa (Canada)
17:15 Pharmacy Data in Epidemiological Studies: An Easy To Obtain and Reliable Tool [122] Taco BM Monster, Wilbert MT Janssen, Paul E de Jong, Lolkje TW de Jong-van den Berg (The Netherlands)
17:30 Using Record Linkage in Combination with Clinical Trials as a Resource for Pharmacoepidemiology [94] Ian Ford, Alex D McMahon (United Kingdom)
17:45 Assessment of a Formula for Converting Odds Ratios To Effect Sizes: Depression Scale Outcomes as a Model [219] Maarten J ten Berg, Michiel EH Hemels, Thomas RE Einarson (The Netherlands & Canada)
19:00-22:30 EVENING AT DYNAMIC EARTH
Admission by ticket only. Ticket includes dinner, transportation and admission.

Tuesday, August 20

Joint ISPE-EURODurg Day

07:00-08:00 Poster Set-up (Hall)
Exhibits Open (Hall)
07:00-08:30 CERTs BREAKFAST ROUNDTABLE UPDATE - 2002 (TBD)
The US Centers for Education and Research in Therapeutics (CERTs) ... a Roundtable [459] Hugh H Tilson, Lynn Bosco, Brian Strom, Wayne Ray
07:00-17:00 Registration (James Watt Lounge)
Speaker Ready Room
08:30-10:15 PLENARY SESSION (James Watt)
Bringing Epidemiology into Drug Utilization Research

Drug Use Method & Importance

Moderators:
Jacques LeLorier, ISPE
Robert Van Stichele, EURODurg

Panelists:
Jerry Avorn, Moving beyond drug utiliztation data to drug appropriateness data
Jesper Hellas, Individual-based drug utilization statistics. How to characterize drug use from data on individual drug dispensing
David Henry, Assessing appropriateness of prescribing with quality indicators in drug utilization research
Keith Beard, Drug use patterns: who decides and how?

10:15-10:45 Refreshment Break/Viewing of Posters & Exhibits (Hall)
10:45-12:45 CONCURRENT SESSIONS
[A] SYMPOSIUM: The Empowerment of Pharmacogenomics by Pharmacoepidemiology [372]
(Lecture 4)
Moderators:
Abraham G Hartzema, University of Florida
M. Lee Morse
[B] SYMPOSIUM: Impact of Drug Safety Scares on Physicians
(James Watt)		 Impact of ADR Scares on Physicians
Moderators:
Stephen Evans , London School of Economics
Alice White, Vice President, Worldwide Epidemiology, GlaxoSmithKline

Panelists:
David Purdie, Hormone Replacement Therapy
Centre for Metabolic Bone Disease, Hull Royal Infirmary, UK

James O Drife, Oral Contraceptives
Professor of Obstetrics & Gynaecology, Claridon Wing, Leeds General Infirmary, UK (Invited)

David Henry, NSAIDs
Department Clinical Pharmacology, Medical Practice & Population Health, Callaghan Campus, University of Newcastle, NSW, Australia

David Salisbury, MMR
Head of Communicable Disease and Immunisation Team, Department of Health, London, UK

12:45-14:30 * Lunch (Dining Area)
* Poster Session B/Viewing of Exhibits (Hall)
* EuroDURG Poster Walk (Hall)
* ISPE Student Council Meeting (TBD)
13:00-14:00 * 2003 ICPE Scientific Program Committee Luncheon (TBD)
(open to all interested members)
14:30-16:00 CONCURRENT SESSIONS (15 minute oral abstract presentations)
[A] Various Topics in Drug Utilization (Lecture 1)
Moderator: Frank May
14:30 Evaluation of the MedMaIDE To Assess Medication Management Deficiencies in the Elderly Living in the Community [197] Denise L Orwig, Nicole J Brandt, Ann L Gruber-Baldini
14:45 Changes of Lipid Profiles after Vitamin E Supplementation: Comparison with Controls without Any Drug Use -Results of the German Federal Health Survey- [54] Hans-Ulrich W Melchert, Yong Du, Hildtraud Knopf, Ellen Pabel, Wulf Thierfelder (Germany)
15:00 Epoetin Alfa: Drug Utilization Study [259] Katerina Mamzoridi, Aliki Tsakalou, Eleni Doulianaki (Greece)
15:15 Medication Management Services: Alleviating Adverse Drug Reactions [87] Andrew L Gilbert, John D Barratt, Elizabeth E Roughead (Australia)
15:30 Medication Use in Community-Dwelling Seniors: Baseline Results from Canadian Randomized Trial [298] Michelle Howard, Janusz Kaczorowski, Connie Sellors, Lisa Dolovich, John Sellors (Canada)
15:45 Lack of Discernable Effects of Retrospective Drug Utilization Review Programs on the Frequency of Presumptive Drug Therapy Problems [194] Sean Hennessy, Warren B Bilker, Colleen Brensinger, Brian L Strom
[B] Bugging the Bugs: Know your Anti-infectives (Lecture 3)
Moderator: Jacque LeLorier
14:30 Antimicrobial Use and Primary Idiopathic Intussusception: A Case-Control Study [119] David M Spiro, Donald H Arnold, Fabio Barbone
14:45 Determinants of Colonization with Antibiotic Resistant Escherichia Coli in Unselected Patients Attending General Practitioners in Germany [208] Til Stürmer, Andrea Erb, Cüneyt Gündogan, Reinhard Marre, Hans-Peter Zeitler, Hermann Brenner (Germany)
15:00 Prevalence and Determinants of Pharyngeal Colonization with Antibiotic Resistant [italic]Haemophilus Parainfluenzae[/italic] among Unselected Patients of General Practitioners in Germany [212] Til Stürmer, Andrea Erb, Susanne Lietzau, Marina Hoewner, Reinhard Marre, Hermann Brenner (Germany)
15:15 Health Outcomes among Patients Receiving Tamiflu [293] Cheryl Enger, Beth Nordstrom, Bharat Thakrar, Susan Sacks, Ken Rothman
15:30 The Effect of Zanamivir Treatment on Influenza Complications [97] J Alexander Cole, Jeanne E Loughlin, Anuli N Ajene, Daniel Rosenberg, Suzanne F Cook, Alexander M Walker
15:45 Low-Level Detectable HIV on Antiretroviral Therapy-Treatment Modifications and Outcomes [241] Leanne Beers, Vincent Lo Re, Jay Kostman, Debra Leonard, Robert Gross
[C] Scanning for Signals (Lecture 4)
Moderator: Wanju Dai
14:30 Practical Use of Automated Databases for Signal Clarification [394] Rhonda L Bohn, Drew G Levy, Juhaeri Juhaeri, Wanju Dai
14:45 Descriptive Case-Series Analysis of Bell¢s Palsy Cases in the Vaccine Adverse Event Reporting System (VAERS) [398] Weigong Zhou, Vitali Pool, Robert P Pless, Robert T Chen
15:00 Respiratory Events in Patients Receiving Inhaled Zanamivir [98] Jeanne E Loughlin, Tanya D Alfredson, Anuli N Ajene, J A Cole, Daniel M Rosenberg, Suzanne F Cook, Alexander M Walker
15:15 Severe Local Reactions Following Booster Doses of DTaP Vaccines in the U.S.: A Signal from the Vaccine Adverse Event Reporting System [325] Vitali Pool, Robert Pless, Robert T Chen
15:30 Drug-Induced Agranulocytosis and Thrombocytopenia: A Review of 20 Years' Experience in a Spontaneous Reporting Scheme [151] Katharina Hartmann, Christian Eggenberger, Max Kuhn (Switzerland)
15:45 Investigation of a Cluster of Cellulitis Following Smallpox Vaccination [369] Christine Casey, Gina Mootrey, Vitali Pool, Robert Pless, Young Hur, Robert Chen
[D] Following the Guidelines: Drug Utilization in Cardiovascular Medicine (Lecture 2)
Moderator: Robert Vander Stichele
14:30 Treatment of Cardiovascular Risk Factors in Type 2 Diabetic Patients - Who Is Not Getting Optimal Treatment? [301] Petra Denig, Willeke N Kasje, Flora M Haaijer-Ruskamp (The Netherlands)
14:45 Assessment of Left Ventricular Function as a Basis for Starting Treatment with ACE Inhibitors after an Acute Myocardial Infarction [131] Åsmund Reikvam, Elena Kvan, Knud Landmark, Ivar Aursnes, INFARM Study Investigators (Norway)
15:00 A Survey of Secondary Prevention of Coronary Heart Disease in Ravenna, Italy [256] Fausto Marchetta, Ezio Degli Esposti, Stefania Saragoni, Giorgia Valpiani, Leona Bassein, Stefano Buda (Italy)
15:15 Incidence and Determinants of CK and Liverfunction Measurements in Patients Using Statins [165] Jeroen J Derijks, Toine CG Egberts (The Netherlands)
15:30 Current Treatment for Chronic Heart Failure in General Practice. Is an Intervention To Improve Prescribing Really Necessary? [300] Willeke N Kasje, Petra Denig, Flora M Haaijer-Ruskamp (The Netherlands)
15:45 Trends in the Prescribing for Heart Failure in General Practice from 1996 to 2000: Do Changes in Prescribing Reflect the Current Evidence? [217] Lisa G Pont, Miriam JCM Sturkenboom, Wiek H van Gilst, Flora M Haaijer-Ruskamp (The Netherlands)
[E] The Highs & Lows in CNS Drug Utilization (James Watt)
Moderators: Thomas Einarson & Flora Haaijer-Ruskamp
14:30 Are Organizational Characteristics Associated with Decreased Use of Selective Serotonin Reuptake Inhibitors (SSRIs) for the Management of Depression in US Nursing Homes? [76] Kate L Lapane, Carmel M Hughes
14:45 Early Discontinuation and Long-Term Therapy in New SSRI Users [331] Welmoed EE Meijer, Eibert R Heerdink, Willem A Nolen, Hubert GM Leufkens (The Netherlands)
15:00 Methods To Identify Treatment-Resistant Depression in a Canadian Claims Database [381] John S Hopkins, Alicia W Gilsenan, Beth H Sherrill, Patricia K Corey-Lisle, Christopher J Longo, Joel Raskin
15:15 Antidepressant Use in People with Diabetes [130] Ross A Lawrenson, John Williams (United Kingdom)
15:30 Selective Prescribing of Zyban : Comparison of Baseline Risks for Subsequent Adverse Events between Zyban Users and All GP Patients in the UK Mediplus Data [157] Leo J Russo, William C Maier
15:45 Pharmacological Treatment for Attention-Deficit Disorder with/without Hyperactivity among Children Aged 18 Years and Younger in the United States, 1996-1999 [391] Tongtong Wang, Boji Huang, Kenneth A Bachmann, Donald B White
16:00-16:30 Refreshment Break/Viewing of Posters & Exhibits (Hall)
16:30-18:00 CONCURRENT SESSIONS (15 minute oral abstract presentations)
[A] Applying Methods (Lecture 2)
Moderator: Mari-Ann Walander
16:30 Validity of Hospital Discharge ICD-Codes for Identifying Patients with Hyponatraemia [58] Kris LL Movig, Hubert GM Leufkens, Albert W Lenderink, Antoine CG Egberts (The Netherlands)
16:45 Use of the Case-Crossover Design To Study Prolonged Drug Exposures and Insidious Outcomes [85] Philip S Wang, Sebastian Schneeweiss, Robert J Glynn, Helen Mogun, Jerry Avorn
17:00 Selection Bias in Observational Studies of Lipid Lowering Drugs [396] Robert J Glynn, Sebastian Schneeweiss, Philip S Wang, Raia Levin, Jerry Avorn
17:15 The Design and Conduct of Cancer Registries (Cohorts) for New Drugs [120] Gerald A Faich
17:30 Linking Registry Data on Severe Skin Reactions with Patient Data from Computerized Medical Practices: Experience of a Pilot Study [220] Maja Mockenhaupt, Juergen Schlingmann, Detlef Schroeder-Bernhardi, Erwin Schoepf (Germany)
17:45 Outpatient Prescriptions in the Emergency Department: Concordance between Patients¢ Charts and Medication Scripts [84] Anick Bérard, Polly E Bijur, E John Gallagher
[B] It Is Not Just in Your Mind (Lecture 1)
Moderator: Corrine de Vries
16:30 The Association between Acute Pancreatitis and Psychotropic Medication [347] Ingo A Eland, Anders S Sundström, Miriam CJM Sturkenboom, Bruno HCh Stricker, Michael JS Langman, Bengt-Erik Wiholm (The Netherlands)
16:45 Less Switching after Initial Start with Atypical Antipsychotics [211] Gerard WK Hugenholtz, Eibert R Heerdink, Willem A Nolen, Hubert GM Leufkens (The Netherlands)
17:00 Risk of Sudden Cardiac Death among Users of Anti-Psychotic Medication [308] Sabine MJM Straus, Gysele S Bleumink, Jeanne P Dieleman, Geert W ¢t Jong, Bruno HCh Stricker, Miriam CJM Sturkenboom (The Netherlands)
17:15 Total Mortality of Nerve/Sleeping Drug Users in a General Middle-Aged Population [453] Svetlana Skurtveit, Aage Tverdal (Norway)
17:30 Urinary Incontinence Induced by Serotonergic Antidepressants [56] Kris LL Movig, Hubert GM Leufkens, Svedlana V Belitser, Bertil W Lenderink, Antoine CG Egberts (The Netherlands)
17:45 Risk of Diabetes and Hyperlipidemia among Atypical Antipsychotics Ambulatory Users [72] Jocelyne Moisan, Jean-Pierre Grégoire, Michel Gaudet, Dan Cooper (Canada)
[C] Women's Health (Lecture 3)
Moderators: Elizabeth Andrews & Lolkje T.W. de Jong van den Berg
16:30 Are Hormone Replacement Therapy (HRT) Users "Healthier" Than Non-Users? Results from the Canadian Multicentre Osteoporosis Study (CaMos) [426] Anick Bérard, Claudie Berger, David Hanley, Susan A Kirkland, Timothy Murray, Jerilynn C Prior, the CaMos Research Group
16:45 Pregnancy and Post-Marketing Medication Safety: Strategies for Pregnancy Detection in Automated Medical Records [385] Janet R Hardy, Theodore R Holford, Gillian C Hall, Michael B Bracken
17:00 Venous Thromboembolism in Women with Androgenic Skin Conditions or PCOS Using Cyproterone Acetate + Ethinyloestradiol: A Nested Case-Control Study [291] Helen E Seaman, Corinne S de Vries, Richard DT Farmer (United Kingdom)
17:15 Incidence Rates of Colonic Ischemia, Serious Complications of Constipation, and Bowel Surgery in Relation to Lotronex Use [316] David P Miller, Suzanne F Cooke, Bruce Sands, Tanya Alfredson, Anuli Ajene, Alexander M Walker
17:30 The Risk of Liver Disease Associated with Cyproterone Acetate + Ethinyloestradiol: A Nested Case-Control Study in Women with Androgenic Skin Conditions or PCOS [292] Helen E Seaman, Corinne S de Vries, Richard DT Farmer (United Kingdom)
17:45 Women with Ischaemic Heart Disease Receive Less Secondary Preventive Therapy but More Anxiolytics Than Men [128] David Williams, Kathleen Bennett, John Feely (Ireland)
[D] The Risk of Drug Use (Lecture 4)
Moderator: Jacques LeLorier
16:30 Conversion from Intravenous to Oral Medications: Assessment of a Computerized Intervention [425] Michael A Fischer, Daniel H Solomon, Jerry Avorn
16:45 Quality Indicators on Prescription Data for Evaluating Appropriateness of Drug Use [436] Alberto Vaccheri, Elisabetta Poluzzi, Davide Resi, Chiara Silvani, Domenico Motola, Nicola Montanaro (Italy)
17:00 Investigation into Causes of Preventable Drug-Related Admissions to a Medical Admissions Unit [145] Rachel L Howard, Anthony J Avery, Paul D Howard, Malcolm Partridge (United Kingdom)
17:15 Non-Steroidal Anti-Inflammatory Drug Use: Impact of Risk Factors for Gastropathy on Prescribing Practices [274] Yola Moride, Thierry Ducruet, Matthew W Reynolds, Sean Z Zhao (Canada)
17:30 Prescribing for Heart Failure in General Practice: The Relationship between Physician Knowledge and Prescribing Quality [257] Lisa G Pont, Wiek H van Gilst, Dirk JA Lok, Hans Kragten, Flora M Haaijer-Ruskamp (The Netherlands)
17:45 Patterns of Topical Glaucoma Drug Utilization [356] Michelle Houde, Anne-Marie Castilloux, Jacques LeLorier (Canada)
[E] Wheezles & Sneezles: Drug Use in Asthma & Infections (James Watt)
Moderators: Debra Rowett
16:30 Use of Inhaled Corticosteroids Following an Emergency Department Visit for Asthma: Determinants of Use among Children and Adolescents [312] Lucie Blais, Sylvie Lévesque, Marie-France Beauchesne (Canada)
16:45 Persistence on Asthma Anti-Inflammatory Agents in Quebec Adult Patients [295] Marc Dorais, Lucie Blais, Jacques LeLorier (Canada)
17:00 Guideline Adherence for the Treatment of Asthma in General Practice Is Associated with a Higher Quality of Life [175] Lisa G Pont, Thys van der Molen, Ger T vander Werf, Flora M Haaijer-Ruskamp (The Netherlands)
17:15 Affecting the Use of Antibiotics in General Practice through Outreach Visits [135] Keld Vaegter, Jens P Kampmann, Jens Kirkegaard, Kim Kristensen, Kurt Svaerdsudd (Denmark)
17:30 Evaluation of Sepsis Management and Intravenous to Oral Antibiotic Switch Protocols [132] Ronald A Seaton, Catherine M McLaughlin, Neena Bodasing, Carl Fenelon, Jonathan Fox (United Kingdom)
17:45 Use of Antibiotics at Hospitals in Stockholm - A Benchmarking Project Using Internet: www.janusinfo.org [370] Ulf Bergman, Helena Risinggård (Sweden)
18:30-20:30 SOCIAL EVENTS (OPTIONAL**)
[A] Military Tattoo
Or
[B] Evening at the Royal College of Physicians of Edinburgh

**Separate registration required- includes dinner, admission & transportation. Limited number of tickets distributed on first-come, first-served basis.

Wednesday, August 21
07:00-08:00 Poster Set-up (Hall)
Exhibits Open (Hall)
07:00-16:00 Registration (James Watt Foyer)
Speaker Ready Room (TBD)
08:00-09:30 CONCURRENT SESSIONS (15 minute oral abstract presentations) Waterfall (Lecture 3)
Moderator: Hubert Leufkens & JW van der Velden
[A] Heartbreakers (Lecture 4)
Moderator: Thomas MacDonald
08:00 Therapeutic Delay and Reduced Functional Status 6 Months after Thrombolysis for Myocardial Infarction [306] Jerry Avorn, Sebastian Schneeweiss, Eric Knight, David A Ganz
08:15 Hospital Mortality and Long Term Mortality in Young Patients with a First Acute Myocardial Infarction: Relation to Statin Adherence [321] Li Wei, Jixian Wang, Suzanne Y Wong, Thomas M MacDonald (United Kingdom)
08:30 A Propensity-Score Matched Cohort Study of the Effect of Statins on Myocardial Infarction [395] John D Seeger, Alexander M Walker, Paige L Williams, Frank M Sacks, Gordon M Saperia
08:45 QTc-Prolonging Drugs and Hospitalization for Cardiac Arrhythmias, a Population Based Case-Control Study [195] Marie L De Bruin, Arno W Hoes, Hubert GM Leufkens (The Netherlands)
09:00 Angiotensin Converting Enzyme Inhibitors Are Associated with an Increased Risk of Acute Pancreatitis [346] Ingo A Eland, Anders S Sundström, Miriam CJM Sturkenboom, Bruno HCh Stricker, Michael JS Langman, Bengt-Erik Wiholm (The Netherlands)
09:15 Long Term Statins Use and Psychological Well-Being [359] Yinong Young-Xu, K Arnold Chan, James K Liao, Shmuel Ravid, Thomas B Graboys, Charles M Blatt
[B] NSAIDS-Selecting Your Pain (James Watt)
Moderators: Anick Berard
08:00 Nonsteroidal Anti-Inflammatory Drug Exposure and the Relative Risk of Colorectal Cancer, Gastrointestinal and Renal Adverse Events [10] Timothy E Niecko, Jeffrey A Kotzan, Joseph T DiPiro, Bradley C Martin
08:15 GI Risk Factors in Patients Prescribed COX-2 Agents and NSAIDs [317] Daniel H Solomon, Raisa Levin, Jerry Avorn
08:30 Stay on Therapy during Three Months of Follow Up of Patients on Selective COX-2 Inhibitors and Other Nonselective NSAIDs in an Elderly Population [187] Elham Rahme, Michael A Marentette, Youssef Toubouti, Sheldon X Kong, Jacques LeLorier (Canada)
08:45 Start of NSAIDs Increases the Risk of Renal Dysfunction in Users of ACE Inhibitors [263] Marcel L Bouvy, Eibert R Heerdink, Arno W Hoes, Hubert GM Leufkens (The Netherlands)
09:00 Comparison of Gastrointestinal Events Reported for Rofecoxib and Meloxicam Using Prescription-Event Monitoring (PEM) Data in England [281] Deborah Layton, Emma Heeley, Kerry Hughes, Saad AW Shakir (United Kingdom)
09:15 Gastrointestinal Complications Associated with Rofecoxib/Celecoxib and Other Nonselective NSAIDs: Analysis of the Government Claims Database in Quebec, Canada [188] Elham Rahme, Michael A Marentette, Youssef Toubouti, Sheldon X Kong, Jacques LeLorier (Canada)
[C] Scotch Blend (Lecture 2)
Moderator: Keith Beard
08:00 Amphotericin B in Documented or Suspected Systemic Fungal Infection: Meta-Analysis of Conventional Versus Lipid Formulations [412] Stacey S MacAulay, Janet E Martin (Canada)
08:15 Meta-Analysis of Placebo Rates in a Defined Population of Patients with Major Depressive Disorder [101] Pieter Stolk, Maarten J ten Berg, Michiel E Hemels, Thomas R Einarson (The Netherlands & Canada)
08:30 Quantifying the Interaction between Aspirin and Angiotensin-Converting-Enzyme Inhibitors: Resolving Discrepancies Using a Meta-Analysis [1] Bahi Takkouche, Mahyar Etminan, Paco Camano, Paula Rochon (Canada)
08:45 Celecoxib and Cardiovascular Thromboses-Methodological Issues in Pooling Trial Data [95] Gerald A Faich, Robert W Makuch, William White
09:00 Evaluation of the Impact of a Varicella Vaccination Program on Incidence of Varicella Disease in an HMO Population [47] John P Mullooly, Julie E Maher, Lois Drew
09:15 The Detection of Preventable Adverse Drug Events among Ambulatory Geriatric Patients [129] Jerry H Gurwitz, Terry Field, Leslie Harrold, Jeffrey Rothschild, Kristin Debellis, Andrew Seger, Cynthia Cadoret, Leslie Fish, Lawrence Garber, Jackie Cernieux, David Bates
[D]
08:00 A Study of the Incidence of Fractures in Men Receiving Medical Therapy for Lower Urinary Tract Symptoms (LUTS) [360] Richard DT Farmer, John W Logie, Nicola Christie (United Kingdom)
08:15 Too Short Course of Trimethoprim or Nitrofurantoin May Lead to an Increased Number of Treatment Failures of Urinary Tract Infections [107] Wim G Goettsch, Ron MC Herings (The Netherlands)
08:30 An Analysis of Cardiac Dysrhythmia in Overactive Bladder Patients Using Tolterodine and Other Overactive Bladder (OAB) Medications [82] Matthew W Reynolds, Sean Z Zhao, John-Kenneth Billingsley, Scott C Henderson
08:45 Burden of Illness of Urinary Incontinence for the Italian NHS: An Exploratory Approach Using Administrative Data [469] Salvatore Mannino, Silvio Cavuto, Lorenzo Colonna, Nicola Groth, Marco Salmoiraghi, Andrea Belloli (Italy)
09:00 Utilization of Macrolides and the Development of Streptococcus Pyogenes Resistance to Erythromycin [92] Karel Urbanek, Milan Kolar (Czech Republic)
09:15 The Use of a-Blockers and 5-a Reductase Inhibitors Decreases the Risk of Prostate Surgery for Patients Diagnosed with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia [233] Katia MC Verhamme, Jeanne P Dieleman, Gysele S Bleumink, Johan van der Lei, Bruno HCh Stricker, Miriam CJM Sturkenboom (The Netherlands)
[E] Money Changes Everything (Lecture 1)
Moderators: Hugh Tilson & Peter Davey
08:00 Incidence, Treatment and Outcomes of Complicated Intra-Abdominal Infections [361] Miriam C Sturkenboom, Wim Goettsch, Bas In¢t Veld, Gino Picelli, Ron MC Herings (Italy)
08:15 Health Care Resource Utilization during One-Year Treatment with Long-Acting Risperidone [213] Adriane R Leal, Devos Emmanuel, Bernard Bernard, Duchesne Inge, Mehnert Angelika (Belgium)
08:30 Net Healthcare Savings from Reference Drug Pricing for Angiotensin-Converting Enzyme Inhibitors [307] Sebastian Schneeweiss, Colin Dormuth, Paul Grootendorst, Malcolm Maclure
08:45 The Impact of Low Dose Aspirin Prescribing on Upper Gastrointestinal Toxicity, Renal Toxicity and Healthcare Resource Utilisation [389] Thomas M MacDonald, Steve V Morant, Alex D McMahon, John GF Cleland, Peter G Davey (United Kingdom)
09:00 Is It Cost-Effective To Improve Compliance with Lipid-Lowering Therapy? [268] Joshua S Benner, David A Ganz, Milton C Weinstein, Peter J Neumann, Robert J Glynn, Jerry Avorn
09:15 Noncompliance with Statin Therapy: Lost Clinical Benefits and Implications for Cost-Effectiveness [267] Joshua S Benner, David A Ganz, Milton C Weinstein, Peter J Neumann, Robert J Glynn, Jerry Avorn
09:30-10:00 Refreshment Break/Viewing of Posters & Exhibits (Hall)
10:00-11:30 CONCURRENT SESSIONS

Symposium - (James Watt)

[A] Drug Related Problems in the Elderly-Epidemiology, Interventions, and Biostatistical Considerations [27] Joseph T Hanlon, Michael D Murray, Duncan R Petty, Carl F Pieper

Workshops [B] - [E] (TBD)

[B] Benefit Risk Analysis: A Proposal Using Epidemiologic Methods [299] William L Holden, Juhaeri Juhaeri, Wanju Dai
[C] Pharmacoepidemiology: Can It Help Evidence-Based Practice? [339] Junius Gonzales, Paul Stang
[D] Measuring the Appropriateness of Drug Use [236] Lynn M Weekes, Flora M Haaijer, Ingrid S Sketris (Australia)
[E] Risk Management: What Are We Driving, Where Are We Going, and How Will We Know When We Get There? [384] Elizabeth B Andrews, Allen A Mitchell, Peter Honig, Suzanne F Cook, Alicia Gilsenan
[F] What's New in GPRD and What Impact Will This Have for Researchers? [379] Susan Eaton, Carlos Martinez, Tim Williams, Lisa McQuay
11:30-13:30 *Lunch (Dining Area)
*Poster Session C/Exhibits (Hall)
*ISPE Board of Directors Luncheon (TBD)
13:30-15:00 CONCURRENT SESSIONS
Symposium (James Watt)
[A] Approaches to Postmarketing Surveillance for Teratogens in the US: Challenges and Progress [276] Stanley A Edlavitch, Dianne L Kennedy, Elizabeth B Andrews, Allen A Mitchell, Janet D Cragan, Jose F Cordero

Workshops [B]- [G] (TBD)

[B] Turning Risks into Opportunities [3] Jan W van der Velden, Ross L. Lawrenson, Annette Stemhagen (The Netherlands, UK, USA )
[C] What Is a Signal? [416]Miles Braun, Begaud Bernard
[D] Pitfalls in the Disproportionality Approach for the Identification of Alerts from Spontaneous Reporting Systems [452] Nicholas D Moore, Gillian Hall, Ron Mann, Miriam Sturkenboom, Rajaa Lagnaoui (France)
[E] Application of Epidemiology in Pre-Approval Drug Development [404] Robert S Brody
[F] The Broader Issues in Drug Safety Case Report Analysis [444] Victor V Gogolak, Ralph Edwards
[G] Prescription-Event Monitoring: Review of the Methodology, Recent Developments and Adaptation to Different Countries [287] Saad AW Shakir, Lynda V Wilton, David M Coulter, Kiyoshi Kubota (United Kingdom)
15:00-16:00 INVITED PLENARY SESSION (James Watt)
Hershel Jick
Principles & Methods in Pharmacoepidemiology Research
16:00-17:30 HOT TOPICS SESSION (James Watt)
COX2-Selective Non-Steroidal Anti-Inflammatory Drugs and Cardiovascular Disease [336]

Moderator: Wayne A Ray

Panelists:
Thomas M MacDonald
Daniel H Solomon
David Graham
Jerry Avorn

17:30-17:45 THE FINAL WORD (James Watt)
Sean Hennessy, Chair, 2003 ICPE Scientific Progam Commitee
17:45 ADJOURNMENT of the 18th ICPE

 

Last Update: 14 August, 2002


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